姓名：李玉娟, 药学博士, 教授，博士生导师

联系方式

地址：北京理工大学生命学院5教615房间

电话：(010)-68914607

电子邮件：lylyjlzh2006@126.com

个人简历

20003年6月于沈阳药科大学获药物分析学博士学位。2003年9月于日本新泻药科大学生命科学部进行博士后研究工作。2005年4月加入北京理工大学生命学院。曾与2012年及2014年前往英国莱斯特大学、美国耶鲁大学进行合作研究。在国内外药学领域相关学术刊物上发表学术论文近百余篇，以主编、参编等身份出版教材及译著8本。获批国家级一流本科线上课程1项。

研究方向

1. 基于核酸适配体分子探针的中药药效物质基础及靶点发现研究。

2. 航天失重神经系统、消化系统损伤分子机制及中医药防护研究。

招生专业

学术型硕士生专业：生物学；专业型硕士专业：生物技术与工程；博士研究生专业：生物学

承担课题

主持四项国家自然科学基金面上项目（82474187、81973572、81573693、81202996）、主持航天军需重大专项（XXXX）、国家重大科学仪器设备开发专项（2012YQ12004410）、国家重点基础研究发展计划、载人航天领域预先研究项目等多项科研项目。

近年部分代表性论文

1. Huayan Liu, Ranran Yan, Yongzhi Li, Jiaping Wang, Yulin Deng，Yujuan Li*, Dragon’s blood attenuates LPS-induced intestinal epithelial barrier dysfunction via upregulation of FAK-DOCK180-Rac1-WAVE2-Arp3 and downregulation of TLR4/NF-κB signaling pathways, J Nat Med,2024, DOI: 10.1007/s11418-024-01824-z

2. Wu, Zhujun; Liu, Huayan; Yan, Liben; Deng, Yifan; Tian, Zhongqin; Du, Yiyang; Zhao, Yuankun; Ma, Hong; Deng, Yu-Lin; Li, Yujuan*; Wang, Zhimin*，Imaging of Gut Bacterial Macroscopic Changes in Simulated Microgravity-Exposed Rats via in vivo Metabolic Labeling, Anal Chem, 2024, doi.org/10.1021

/acs.analchem.4c05028

3. Huayan liu; Min Liang; Yulin Deng; Yujuan Li*. Simulated Microgravity Alters P-Glycoprotein Efflux Function and Expression via the Wnt/β-Catenin Signaling Pathway in Rat Intestine and Brain. I Int J Mol Sci, 2023, doi: ijms2406543

4. Huayan Liu, Xin Zhang, Yujiao Liu, Nian Xin, Yulin Deng*, Yujuan Li*, Semen Ziziphi Spinosae attenuates blood-brain barrier dysfunction induced by lipopolysaccharide by targeting the FAK-DOCK180-Rac1-WAVE2-Arp3 signaling pathway, NPJ Sci Food, 2022, doi: 10.1038/s41538-022-00142-6

5. Yujuan Li*, Shan Liu, Huayan Liu, Yaoyuan Cui and Yulin Deng，Dragon’s blood regulates Rac1‑WAVE2‑Arp2/3 signaling pathway to protect rat intestinal epithelial barrier dysfunction induced by simulated microgravity, Int J Mol Sci, 2021, doi.org/10.3390/ijms22052722

6. Yujuan Li*, Lili Huang, Javed Iqbal, Yulin Deng, Study of P-glycoprotein interaction proteins in rat brain under simulated microgravity-Labeled free comparative proteomics approach, Space: Sci & Tech, 20210201.

7. Ranran Yan, Huayan Liu, Fang Lv, Yulin Deng, Yujuan Li*, Rac1/Wave2/Arp3 pathway mediates rat Blood-Brain Barrier dysfunction under simulated microgravity based on proteomics strategy, Int J Mol Sci, DOI: 10.3390/ijms22105165

8. Shibo Wang, Rui Wang, George Q. Li, Jun-Lae Cho, Yulin Deng, Yujuan Li*, Simulated microgravity effect could increase the intestinal epithelium permeability by enhancement of myosin light chain phosphorylation: a proteomic approach, J Prote, 2020, doi: 10.1016/j.jprot.2020.104001.

9. Bo Chen, George Q Li, Yongzhi Li, Jun Lae Cho, Jiaping Wang, Jianyi Gao, Yulin Deng，Yujuan Li*，Proteomic changes related to energy metabolism and oxidative stress in rat exposed to simulated microgravity, Acta Astronautica, 2020, doi: 10.1016/j.actaastro.2020.02.007.