郭淑元，理学博士，现为北京理工大学生命学院教授，博士生导师，北京理工大学研究生院督导组督导专家。

一、联系方式

地址：北京理工大学生命学院

电子邮件：guosy @bit.edu.cn

二、教育背景

清华大学生物科学与技术系，获博士学位；

东北农业大学生物工程系获学士、硕士学位；

三、研究领域/方向

      研究方向为基于人工智能的微生物基因组快速编辑方法的建立及优化、微生物与宿主的互作机理、生物活性蛋白的功能与应用开发等。

具体研究内容包括但不限于：

1. 蛋白质的结构、功能及应用研究；

2. 基于人工智能算法，设计及优化基因编辑方法，实现微生物基因组的高效编辑；

3. 利用CRISPR/Cas9等基因编辑技术，构建高效微生物细胞工厂；

4. 探究微生物（芽胞杆菌）与宿主的互作机理。

参加国家重点研发专项、国家自然科学基金国际合作重点项目、国家科技部973、863等项目研究，主持国家自然基金项目等。

四、近五年代表性文章

1.         Yan Xia, Jinyuan Sun, Xiaowen Du, Zeyu Liang, Xin Wu, Wenyu Shi, Bin Shao, Shuyuan Guo*, Yi-Xin Huo*, Design prokaryotic cis-regulatory elements using language model. Nucleic Acids Research, 2026, 54, gkag122. https://doi.org/10.1093/nar/gkag122.

2.         Zeyu Liang, Zhaojin Ye, Yan Xia, Xiaowen Du, Lichao Sun, Xiaoyan Ma, Shuyuan Guo^*, Yi-Xin Huo^*. One-round-per-day CRISPR genome editing of E. coli for engineering green-chemical overproducer. Chemical Engineering Journal, 2025, 503: 158453.

3.         Yan Xia, Zeyu Liang, Xiaowen Du, Dengtian Cao, Jing Li, Lichao Sun, Yi-Xin Huo*, Shuyuan Guo*, Design of function-regulating RNA via deep learning and AlphaFold 3, Briefings In Bioinformatics, 2025, 26(4), bbaf419. DOI: 10.1093/bib/bbaf419.

4.         Yan Xia, Lichao Sun, Zeyu Liang, Zhongrao Han, Jing Li, Pengyu Dong, Yi-Xin Huo*, Shuyuan Guo*, Chromosome-segment scanning for gain- or loss-of-function screening (CHASING), iScience, 2025, 28, 112484.

5.         Jianbo Yang, Yan Xia, Li Zhu, Zhiwen Wang, Fuping Song*, Shuyuan Guo*. Screening signal peptides from Bacillus thuringiensis secretome for heterologous protein secretion. Applied Microbiology and Biotechnology, 2025, 109:147.

6.         Qi Peng, Jiaxin Qin, Hong Xu, Guiwei Kao, Fan Yang, Zhongqin Sun, Xin Zhang, Leyla Slamti, Shuyuan Guo*, Fuping Song*. Rapid adaptation of Bacillus thuringiensis to alkaline environments via the L-lactate metabolism pathway regulated by the CRP/FNR family regulator LtmR. Pesticide Biochemistry and Physiology, 2025, 208: 106255. DOI: 10.1016/j.pestbp.2024.106255

7.         Yan Xia, Xiaowen Du, Bin Liu, Shuyuan Guo*, Yi-Xin Huo*. Species-specific design of artificial promoters by transfer-learning based generative deep-learning model. Nucleic Acids Research. 2024, 52(11): 6145-6157.

8.         Pengyu Dong, Yunjuan Fan, Yi-Xin Huo, Lichao Sun*, Shuyuan Guo*, Pathway-Adapted Biosensor for High-Throughput Screening of O‑Methyltransferase and its Application in Vanillin Synthesis. ACS Synth. Biol. 2024, 13, 2873−2886.

9.         Yan Xia, Lichao Sun, Zeyu Liang, Yingjie Guo, Jing Li, Dan Tang, Yi-Xin Huo*, Shuyuan Guo*. The construction of a PAM-less base editing toolbox in Bacillus subtilis and its application in metabolic engineering. Chemical Engineering Journal, 2023, 469, 143865.

10.     Ying Liu, Lichao Sun*, Yi-Xin Huo, Shuyuan Guo*. Strategies for improving the production of bio-based vanillin. Microbial Cell Factories, 2023, 22: 147.

11.     Changgeng Xu, Qin Zou, Jiheng Tian, Mengyuan Li, Baowen Xing, Julia Gong, Jiangyun Wang*, Yi-Xin Huo*, Shuyuan Guo*. Simplified Construction of Engineered Bacillus subtilis Host for Improved Expression of Proteins Harboring Noncanonical Amino Acids. ACS Synthetic Biology, 2023, 12(2):583-595.

12.     Jiheng Tian, Baowen Xing, Mengyuan Li, Changgeng Xu, Yi-Xin Huo*, Shuyuan Guo*. Efficient Large-Scale and Scarless Genome Engineering Enables the Construction and Screening of Bacillus subtilis Biofuel Overproducers. International Journal of Molecular Sciences, 2022, 23, 4853.

13.     Mengyuan Li, Yi-Xin Huo*, Shuyuan Guo*. CRISPR-Mediated Base Editing: From Precise Point Mutation to Genome-Wide Engineering in Nonmodel Microbes. Biology, 2022, 11, 571.