1. 个人简介：

阮少波，北京理工大学生命学院，长聘副教授/特别研究员，博士生导师。主要从事脑靶向递药系统设计与开发。研究成果以通讯/第一作者在Sci. Adv.、ACS Nano、Adv. Funct. Mater.、J. Extracell. Vesicle、Nano Lett.、Adv. Sci.、Biomaterials等期刊发表SCI论文30多篇，3篇论文入选ESI高被引，总他引次数5000多次，H因子34；主持并参与创新药物研发国家科技重大专项、国家自然科学基金、北自然海淀联合、北京理工大学学术启动计划项目5项；担任Exploration学术编辑、Acta Pharmaceutica Sinica B青年编委、Asian Journal of Pharmaceutical Sciences青年编委、Chinese Chemical Letters青年编委；担任中国医药生物技术协会生物制药技术分会委员。

2. 招生信息：

招生专业：药学/生物学/生物技术与工程

联系方式：ruanshaobo@bit.edu.cn

3. 研究方向：

（1）脑靶向递药系统设计与开发

（2）核酸药物递送

（3）癌症疫苗研发

4. 教育背景：

（1）2015.09-2018.06，四川大学华西药学院，药剂学，理学博士；

（2）2012.09-2015.06，四川大学华西药学院，药剂学，理学硕士；

（3）2008.09-2012.07，皖南医学院，药物制剂，理学学士。

5. 工作经历：

（1）2026.01-至今，北京理工大学生命学院，长聘副教授/特别研究员，博士生导师；

（2）2021.09-2026.01，北京理工大学前沿交叉科学院，预聘/长聘副教授，博士生导师；

（3）2020.07-2021.07，美国佛罗里达大学，博士后；

（4）2018.07-2020.06，美国堪萨斯大学，博士后。

6. 获奖与荣誉：

（1）Wiley中国高贡献作者奖；

（2）北京理工大学第四届教师教学创新大赛三等奖；

（3）博士研究生国家奖学金（2016）；

（4）硕士研究生国家奖学金（2015）。

7. 主持项目：

（1）创新药物研发国家科技重大专项，项目骨干，在研，50万；

（2）国家自然科学基金面上项目，主持，在研，50万；

（3）国家自然科学基金青年项目，主持，在研，30万；

（4）北京市自然科学基金-海淀原始创新联合基金，主持，结题（优秀），29.3万；

（5）北京理工大学青年学者启动计划，主持，结题，60万。

8. 代表性论文：

(1) Wenpei Li, Shaoping Jiang, Kun Liu, Zhi Li, Jun Yang, Weimin Liu, Yuanyu Huang, Minghui Yang, Shuai Guo*, Shaobo Ruan*. Exosome Secretion Drives Chemo-Resistance of Temozolomide in Glioblastoma. Journal of Extracellular Biology, 2026, 5, e70161.

(2) Zhi Li, Shaoping Jiang, Jie Wang, Wenpei Li, Jun Yang, Weimin Liu, Huile Gao, Yuanyu Huang, Shaobo Ruan*. Peptide-drug conjugates repolarize glioblastoma-associated macrophages to resensitize chemo-immunotherapy of glioblastoma. Science Advances, 2025, 11, eadr8841.

(3) Zhaohan Li, Jun Yang, Jianan Li, Shuxuan Zhao, Shaoping Jiang, Weimin Liu, Xinjian Li, Simeng Zhang, Haiyan Du, Junjun Ni, Yuanyu Huang*, Hong Qin*, Shaobo Ruan*. Targeted delivery of BACE1 siRNA for synergistic treatment of Alzheimer’s disease. Translational Neurodegeneration, 2025, 14, 41.

(4) Jianan Li, Jun Yang, Shaoping Jiang, Yunxin Tian, Yuquan Zhang, Lin Xu, Bo Hu, Huiping Shi, Zhaohan Li, Guangyao Ran, Yuanyu Huang*, Shaobo Ruan*. Targeted Reprogramming of Tumor-Associated Macrophages for Overcoming Glioblastoma Resistance to Chemotherapy and Immunotherapy. Biomaterials, 2024, 311, 122708.

(5) Jun Yang^#, Yong Li^#, Shaoping Jiang, Yuxin Tian, Mengjie Zhang, Shuai Guo, Pengfei Wu, Jianan Li, Lin Xu, Wenpei Li, Yushu Wang, Huile Gao, Yuanyu Huang, Yuhua Weng*, Shaobo Ruan*. Engineered Brain-Targeting Exosome for Reprogramming Immunosuppressive Microenvironment of Glioblastoma. Exploration, 2024, 20240039.

(6) Shaoping Jiang, Wenpei Li, Jun Yang, Tian Zhang, Yuquan Zhang, Lin Xu, Bo Hu, Zhi Li, Huile Gao*, Yuanyu Huang*, Shaobo Ruan*. Cathepsin B-Responsive Programmed Brain Targeted Delivery System for Chemo-Immunotherapy Combination Therapy of Glioblastoma. ACS Nano 2024, 18(8), 6445-6462.

(7) Zhi Li, Wenpei Li, Shaobo Jiang, Chuan Hu, Yuanyu Huang, Maxim Shevtsov, Huile Gao*, Shaobo Ruan*. Legumain-triggered aggregable gold nanoparticles for enhanced cellular and intratumoral retention. Chin. Chem. Lett. 2024, 35(7), 109150.

(8) Lulu. Zheng, Bo Hu, Deyao Zhao, Wenjing Liu, Qing Liu, Yuanyu Huang*, Shaobo Ruan*. Recent progresses of exosome-liposome fusions in drug delivery. Chin. Chem. Lett., 2024, 35(2), 108647.

(9) Rui Liu, Cong Luo, Zhiqing Pang, Jinming Zhang, Shaobo Ruan, Meiying Wu, Lei Wang, Tao Sun, Nan Li, Liang Han, Jinjin Shi, Yuanyu Huang, Weisheng Guo, Shaojun Peng, Wenhu Zhou, Huile Gao *. Advances of nanoparticles as drug delivery systems for disease diagnosis and treatment. Chin. Chem. Lett. 2023; 34(2):107518.

(10) Shaobo Ruan, Nina Erwin, Mei He*. Light-induced high-efficient cellular production of immune functional extracellular vesicles. J. Extracell. Vesicles, 2022, 11(3), e12194.

(11) Shaobo Ruan*, Yuanyu Huang, Mei He, Huile Gao. Advanced biomaterials for cell-specific modulation and restore of cancer immunotherapy. Adv. Sci., 2022, 2200027.

(12) Rou Xie^#, Shaobo Ruan^#, Jiaqi Liu, Lin Qin, Chuanyao Yang, Fan Tong, Ting Lei, Maxim Shevtsov, Huile Gao* and Yi Qin*. Furin-instructed aggregable gold nanoparticles for re-educating tumor associated macrophages and overcoming breast cancer chemoresistance. Biomaterials, 2021, 120891.

(13) Shaobo Ruan, Z.F. Greenberg, X.S. Pan, Pei Zhuang, Nina Erwin, Mei He*. Engineering Extracellular Vesicles for Advancing Cancer Immunotherapy. Adv. Healthc. Mater., 2021, 2100650.

(14) Shaobo Ruan, Yang Zhou, Xinguo Jiang, Huile. Gao*. Rethinking CRITID procedure of brain targeting drug delivery: circulation, blood brain barrier recognition, intracellular transport, diseased cell targeting, internalization, and drug release (CRITID). Adv. Sci., 2021, 2004025.

(15) Shaobo Ruan^#, Rou Xie^#, Lin Qin, Meinan Yu, Wei Xiao, Chuan Hu, Wenqi Yu, Zhiyong Qian, Liang Ouyang, Qin He, Huile Gao*. Aggregable nanoparticles-enabled chemotherapy and autophagy inhibition combined with anti-PD-L1 antibody for improved glioma treatment. Nano Lett., 2019, 19, 8318-8332.

(16) Shaobo Ruan, Lin Qin, Wei Xiao, Chuan Hu, Yang Zhou, Ranran Wang, Xing Sun, Wenqi Yu, Qin He and Huile Gao*. Acid-responsive transferrin dissociation and GLUT mediated exocytosis for increased blood-brain barrier transcytosis and programmed glioma targeting delivery. Adv. Funct. Mater., 2018, 1802227.

(17) Shaobo Ruan, Wei Xiao, Chuan Hu, Huajin Zhang, Jingdong Rao, Sihan Wang, Xiao Wang, Qin He* and Huile Gao*. Ligand-Mediated and Enzyme-Directed Precise Targeting and Retention for Enhanced Treatment of Glioblastoma. ACS Appl. Mater. Interfaces, 2017, 9, 20348-20360.

(18) Shaobo Ruan, Chuan Hu, Xian Tang, Xingli Cun, Wei Xiao, Kairong Shi, Qin He and Huile Gao*. Increased Gold Nanoparticle Retention in Brain Tumors by in Situ Enzyme-Induced Aggregation. ACS Nano, 2016, 10, 10086-10098.

(19) Shaobo Ruan, Mingqing Yuan, Li Zhang, Guanlian Hu, Jiantao Chen, Xingli Cun, Qianyu Zhang, Yuting Yang, Qin He* and Huile Gao*. Tumor microenvironment sensitive doxorubicin delivery and release to glioma using angiopep-2 decorated gold nanoparticles. Biomaterials, 2015, 37, 425-435.

(20) Shaobo Ruan, Xi Cao, Xingli Cun, Guanlian Hu, Yi Zhou, Yijia Zhang, Libao Lu, Qin He and Huile Gao*. Matrix metalloproteinase-sensitive size-shrinkable nanoparticles for deep tumor penetration and pH triggered doxorubicin release. Biomaterials, 2015, 60, 100-110.

9. 申请/授权专利

（1）阮少波，李植；刺激响应性多肽偶联 药物自组装的超分子纳米粒制备及在脑肿瘤中的应用，ZL202411846786.9

（2）高会乐，何勤，阮少波；angiopep-2修饰的荧光碳纳米粒在脑肿瘤诊断中的应用，ZL201410157415.X